Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2BDAW)

• Drug Name: SK&F-S-106203 Drug Info
• Synonyms: SK&F-106203; (S)-beta-[(2-Carboxyethyl)thio]-2-(8-phenyloctyl)benzenepropanoic acid; 3(S)-[2-(Carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propionic acid

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 3035514
  CAS Number: CAS 129047-98-9
  TTD Drug ID: DM2BDAW

Molecule-Related Drug Atlas

Drug(s) Targeting Leukotriene receptor (LTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SR-2640	DMFDA4Y	Asthma	CA23	Phase 2	[3]
Ontazolast	DMS8Q7A	Asthma	CA23	Phase 2	[4]
PIRODOMAST	DMC3T2S	Asthma	CA23	Phase 2	[5]
WF-11605	DM57FHW	Bacterial infection	1A00-1C4Z	Phase 1	[6]
FK-664	DMFGJNW	Cardiac disease	BA00-BE2Z	Discontinued in Phase 2	[7]
SMP-028	DMQSGOD	Asthma	CA23	Discontinued in Phase 1	[8]
NZ-107	DMXJO5F	Asthma	CA23	Discontinued in Phase 1	[9]
ABT-080	DMTYWE9	Asthma	CA23	Discontinued in Phase 1	[10]
BAY-Y-1015	DM0UEKF	Inflammation	1A00-CA43.1	Discontinued in Phase 1	[11]
ICI-198615	DM0195G	Asthma	CA23	Terminated	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukotriene receptor (LTR)	TTTWGIX	NOUNIPROTAC	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000042)
• [2] Pharmacologic and pharmacokinetic profile of SK&F S-106203, a potent, orally active peptidoleukotriene receptor antagonist, in guinea-pig. Pulm Pharmacol. 1991;4(3):177-89.
• [3] Effect of the leukotriene LTD4/LTE4 antagonist, SR 2640, in ulcerative colitis: an open clinical study. Prostaglandins Leukot Essent Fatty Acids. 1991 Mar;42(3):181-4.
• [4] Effects of progesterone and leukotriene receptor antagonists in experimental models of P-glycoprotein-related resistance. Eur J Med Res. 1997 Apr 21;2(4):159-64.
• [5] Antiallergy activity of Sch 37224, a new inhibitor of leukotriene formation. J Pharmacol Exp Ther. 1988 Dec;247(3):997-1003.
• [6] WF11605, an antagonist of leukotriene B4 produced by a fungus. II. Structure determination. J Antibiot (Tokyo). 1992 May;45(5):704-8.
• [7] US patent application no. 7,175,854, Pharmaceutical preparation comprising an active dispersed on a matrix.
• [8] Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats. Toxicol In Vitro. 2014 Apr;28(3):397-402.
• [9] Effects of NZ-107 on tracheal responses to adenosine in the guinea pig. Jpn J Pharmacol. 1991 May;56(1):79-84.
• [10] An update on the role of leukotrienes in asthma. Curr Opin Allergy Clin Immunol. 2010 February; 10(1): 60-66.
• [11] The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation. Arthritis Rheum. 1996 Mar;39(3):515-21.
• [12] In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist. J Pharmacol Exp Ther. 1987 Nov;243(2):548-56.