General Information of Drug (ID: DM2DAFS)

Drug Name
ATPA Drug Info
Synonyms
ATPA; AC1Q6BQV; AC1L1D9I; 3-(5-tert-butyl-3-hydroxy-1,2-oxazol-4-yl)alanine; GTPL4140; HMS3260K20; Tox21_500139; LP00139; CCG-204234; NCGC00093629-02; NCGC00093629-01; NCGC00015027-03; NCGC00015027-02; NCGC00260824-01; NCGC00015027-04; EU-0100139; 2-azaniumyl-3-(5-tert-butyl-3-oxo-1,2-oxazol-4-yl)propanoate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2253
ChEBI ID
CHEBI:91806
CAS Number
CAS 140158-50-5
TTD Drug ID
DM2DAFS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [3]
LY293558 DM4N6EK Pain MG30-MG3Z Phase 2 [4]
NS 1209 DM9EFH0 Epilepsy 8A60-8A68 Phase 2 [5]
NBQX DMPHZI5 Neurological disorder 6B60 Phase 1 [6]
YM-90K DMWRT4L Convulsion 8A68.Z Discontinued in Phase 2 [6]
[3H]kainate DMMK7XU Discovery agent N.A. Investigative [2]
[3H]quisqualate DMDQBTX Discovery agent N.A. Investigative [7]
SYM2081 DM30WDL Discovery agent N.A. Investigative [2]
DNQX DMQXPA5 Discovery agent N.A. Investigative [8]
dysiherbaine DM0EBAF Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor ionotropic kainate 1 (GRIK1) TT0MYE2 GRIK1_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4140).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450).
3 Development of medications for alcohol use disorders: recent advances and ongoing challenges. Expert Opin Emerg Drugs. 2005 May;10(2):323-43.
4 Pharmacogenetics of new analgesics. Br J Pharmacol. 2011 Jun;163(3):447-60.
5 The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9.
6 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7.
7 Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotr... J Med Chem. 2008 Jul 24;51(14):4093-103.
8 Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.