Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2IEB7)

Drug Name

Anti-CD30-CAR T cells Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Hodgkin lymphoma	2B30	Phase 1	[1]
Large cell lymphoma	2A80.Z	Phase 1	[1]
Lymphoma	2A80-2A86	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Lymphocyte activation antigen CD30 (TNFRSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Brentuximab vedotin	DMWLC57	Hodgkin lymphoma	2B30	Approved	[2]
AFM13	DMN45IC	Hodgkin lymphoma	2B30	Phase 2	[3]
Iratumumab	DMI874B	Lymphoma	2A80-2A86	Phase 2	[4]
SGN-30	DMJ9M5D	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
CAR-T cells targeting CD30	DML0KWM	Non-hodgkin lymphoma	2B33.5	Phase 2	[6]
CAR-T cells targeting CD30	DML0KWM	Non-hodgkin lymphoma	2B33.5	Phase 2	[7]
TT11X	DMW3M7X	Hodgkin lymphoma	2B30	Phase 2	[8]
TT20X	DMHGI09	Aggressive cancer	2A00-2F9Z	Phase 2	[8]
4SCAR19 and 4SCAR30	DMUYFS1	B-cell lymphoma	2A86	Phase 1/2	[9]
Anti-CD30 CAR T cells	DM8139V	Lymphoma	2A80-2A86	Phase 1/2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lymphocyte activation antigen CD30 (TNFRSF8)	TT2GM5R	TNR8_HUMAN	CAR-T-Cell-Therapy	[1]

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References

1	ClinicalTrials.gov (NCT03049449) T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas
2	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
3	Clinical pipeline report, company report or official report of Affimed Therapeutics.
4	Utilizing CD30 expression as a rational target for therapy of lymphoma. J Hematol Oncol. 2012; 5(Suppl 1): A2.
5	The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease. Cancer Res. 2002 Jul 1;62(13):3736-42.
6	ClinicalTrials.gov (NCT03196830) CAR-T for R/R B-NHL
7	ClinicalTrials.gov (NCT03312205) CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies
8	Clinical pipeline report, company report or official report of Tessa Therapeutics
9	ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies
10	ClinicalTrials.gov (NCT02274584) CAR T Cells Targeting CD30 Positive Lymphomas (4SCAR30273)