Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2RH51)

• Drug Name: SCH-42495 Drug Info
• Synonyms: N-[2(S)-(Acetylsulfanylmethyl)-3-(2-methylphenyl)propionyl]-L-methionine ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Hypotension	BA20-BA21	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 131965
  CAS Number: CAS 136511-43-8
  TTD Drug ID: DM2RH51

Molecule-Related Drug Atlas

Drug(s) Targeting Neutral endopeptidase (MME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LCZ696	DMLFX7K	Heart failure	BD10-BD13	Approved	[3]
Candoxatril	DMHJCGV	Hypertension	BA00-BA04	Phase 3	[4]
Gallopamil	DMXBR27	Asthma	CA23	Phase 2	[5]
SLV 306	DMCDON3	Acute decompensated heart failure	BD1Z	Phase 2	[6]
SLV-334	DMXCJKY	Brain injury	NA07.Z	Phase 2	[7]
VX-15	DMLWM4G	Huntington disease	8A01.10	Phase 2	[8]
Sampatrilat	DMXTOVE	Hypotension	BA20-BA21	Phase 2	[9]
SLV-338	DM7WKTM	Cardiovascular disease	BA00-BE2Z	Phase 1	[10]
GW-796406	DMQ46DN	Hypotension	BA20-BA21	Phase 1	[5]
Debio 0827	DMQIEFB	Chronic pain	MG30	Phase 1	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutral endopeptidase (MME)	TT5TKPM	NEP_HUMAN	Inhibitor	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002070)
• [2] Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension. Hypertension. 1993 Jul;22(1):119-26.
• [3] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [4] Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Indian Pacing Electrophysiol J. 2008 Apr 1;8(2):102-13.
• [5] Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13.
• [6] The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8.
• [7] Clinical trials in traumatic brain injury: past experience and current developments.Neurotherapeutics.2010 Jan;7(1):115-26.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Sustained antihypertensive actions of a dual angiotensin-converting enzyme neutral endopeptidase inhibitor, sampatrilat, in black hypertensive subjects. Am J Hypertens. 1999 Jun;12(6):563-71.
• [10] Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage. Clin Lab. 2011;57(7-8):507-15.
• [11] Clinical pipeline report, company report or official report of Debiopharm (2011).