Details of the Drug

General Information of Drug (ID: DMLWM4G)

Drug Name

VX-15

Synonyms

VX-15/2503; Plexin B1 antagonist (autoimmune disease/cancer), Vaccinex; Anti-CD100 MAb (autoimmune disease/cancer), Vaccinex;Anti-semaphorin 4D monoclonal antibody (autoimmune disease/cancer), Vaccinex

Indication

Disease Entry	ICD 11	Status	REF
Huntington disease	8A01.10	Phase 2	[1]
Multiple sclerosis	8A40	Phase 1	[2]
Non-small-cell lung cancer	2C25.Y	Phase 1	[3]
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Drug Type

Antibody

Cross-matching ID

TTD ID: D0N1SH

Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutral endopeptidase (MME)	TT5TKPM	NEP_HUMAN	Inhibitor	[4]
Semaphorin-4D (SEMA4D)	TT5UT28	SEM4D_HUMAN	Not Available	[5]

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Molecular Interaction Atlas (MIA)

MIA Detail

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT01764737) Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MS. U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Soli... Clin Cancer Res. 2016 Feb 15;22(4):827-36.