Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2WS8B)

Drug Name

D-AP4 Drug Info

Synonyms

D-AP4; 78739-01-2; (2R)-2-amino-4-phosphonobutanoic acid; (R)-2-Amino-4-phosphonobutanoic acid; d(-)-2-amino-4-phosphonobutyric acid; Tocris-0101; Tocris-0102; D-APB; AC1LT3KN; Lopac-A-1910; GTPL1443; SCHEMBL12648443; CHEMBL1319383; CTK2I0929; BDBM82006; MolPort-004-956-473; ZINC1656225; PDSP1_000361; PDSP2_000359; BN0083; (r)-2-amino-4-phosphonobutyric acid; AKOS024456336; FCH3604711; API0009835; NCGC00024467-01; D-(-)-2-Amino-4-phosphonobutyric acid; NCGC00024466-01; NCGC00015041-02; NCGC00015041-01; B6201; FT-0772107; Butanoic acid, 2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1550579
TTD Drug ID: DM2WS8B

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Metabotropic glutamate receptor 8 (mGluR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[3]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[4]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[3]
(1S,3R)-ACPD	DM5DOAF	Discovery agent	N.A.	Investigative	[2]
MAP4	DMUCE93	Discovery agent	N.A.	Investigative	[5]
MPPG	DMJHQ9T	Discovery agent	N.A.	Investigative	[2]
alpha-methylserine-O-phosphate	DMCIH1X	Discovery agent	N.A.	Investigative	[6]
L-AP4	DMPJFGI	Discovery agent	N.A.	Investigative	[3]
(S)-3,4-DCPG	DMG5BUA	Discovery agent	N.A.	Investigative	[7]
ACPT-I	DM264XN	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 8 (mGluR8)	TT0IFKL	GRM8_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1443).
2	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97.
3	Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10.
4	Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9.
5	Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):180-90.
6	The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317.
7	(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8.
8	Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. Eur J Pharmacol. 2000 Apr 7;394(1):17-26.