General Information of Drug (ID: DM314CZ)

Drug Name
REV-598 Drug Info
Synonyms EV-598
Indication
Disease Entry ICD 11 Status REF
Carcinoid syndrome 5B10 Terminated [1]
Cross-matching ID
TTD Drug ID
DM314CZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug(s) Targeting Histamine receptor (HR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Histamine Phosphate DMV7IM6 Diagnostic imaging N.A. Approved [3]
Repirinast DM6KI0D Asthma CA23 Approved [4]
Levomequitazine DMAYC76 Seasonal allergic rhinitis CA08.01 Phase 3 [5]
ETX-9101 DMZOA2L Asthma CA23 Phase 2 [6]
LCB-2183 DMY4IWC Asthma CA23 Phase 2 [7]
ETS-6218 DMV96BY Fibromyalgia MG30.01 Phase 2 [6]
Votucalis DMW4LTI Allergic rhinitis CA08.0 Phase 2 [8]
OX-NLA DMPEHBJ Allergic rhinitis CA08.0 Discontinued in Phase 3 [9]
Tesmilifene DMPB36I Breast cancer 2C60-2C65 Discontinued in Phase 2 [10]
CP-118 DMNJD9H Allergic rhinitis CA08.0 Discontinued in Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting 5-HT receptor (5HTR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [12]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [13]
Ramosetron DMH7GN8 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [12]
Pizotyline DMV74ZH Headache 8A80-8A84 Approved [13]
Tandospirone DMPHWU6 Anxiety disorder 6B00-6B0Z Approved [12]
Nafronyl DMVMQ1L Cerebrovascular ischaemia 8B1Z Approved [13]
ITI-007 DMUQ1DO Depression 6A70-6A7Z Phase 3 [14]
Fenfluramine DM0762O Dravet syndrome 8A61.11 Phase 3 [15]
MIN-117 DMSLIW6 Major depressive disorder 6A70.3 Phase 2 [14]
Lu-AA34893 DM2ZUXK Anxiety disorder 6B00-6B0Z Phase 2 [16]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT receptor (5HTR) TT85JO3 NOUNIPROTAC Inhibitor [2]
Histamine receptor (HR) TT7CXIM NOUNIPROTAC Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819)
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819)
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Mechanism of action of MY-1250, an active metabolite of Repirinast, in inhibiting histamine release from rat mast cells. Br J Pharmacol. 1992 Mar;105(3):587-90.
5 Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42.
6 Clinical pipeline report, company report or official report of e-Therapeutics.
7 LCB 2183 inhibits the inflammation associated with oxazolone-induced contact sensitivity. Int J Immunopharmacol. 1994 Aug;16(8):675-83.
8 CA patent application no. 520580, Histamine binding compounds for treatment method for disease conditions mediated by neutrophils.
9 Clinical pipeline report, company report or official report of Orexo.
10 Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. J Pharm Pharmacol. 2010 Aug;62(8):1084-8.
11 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025139)
12 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
13 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
14 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
15 Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418.
16 Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105).