Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM346QI)

Drug Name

Capreomycin Sulfate Drug Info

Synonyms

Capastat Sulfate

Indication

Disease Entry	ICD 11	Status	REF
Tuberculosis	1B10-1B1Z	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Bacterial 70S ribosomal RNA (Bact 70S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capreomycin	DMNZBRY	Bacterial infection	1A00-1C4Z	Approved	[3]
Viomycin sulfate	DMZYLFC	Bacterial infection	1A00-1C4Z	Approved	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 70S ribosomal RNA (Bact 70S rRNA)	TTIA0J5	NOUNIPROTAC	Modulator	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.Nat Struct Mol Biol.2010 Mar;17(3):289-93.
3	Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli. Mol Genet Genomics. 2007 Sep;278(3):307-15.
4	The antibiotic viomycin traps the ribosome in an intermediate state of translocation.Nat Struct Mol Biol.2007 Jun;14(6):493-7.