Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTIA0J5)

DTT Name Bacterial 70S ribosomal RNA (Bact 70S rRNA)
Gene Name Bact 70S rRNA
DTT Type
Successful target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T48472

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capreomycin DMNZBRY Bacterial infection 1A00-1C4Z Approved [1]
Capreomycin Sulfate DM346QI Tuberculosis 1B10-1B1Z Approved [2]
Viomycin sulfate DMZYLFC Bacterial infection 1A00-1C4Z Approved [3]
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References

1 Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli. Mol Genet Genomics. 2007 Sep;278(3):307-15.
2 The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.Nat Struct Mol Biol.2010 Mar;17(3):289-93.
3 The antibiotic viomycin traps the ribosome in an intermediate state of translocation.Nat Struct Mol Biol.2007 Jun;14(6):493-7.