Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM35KDA)

Drug Name

Ataciguat Drug Info

Synonyms

Ataciguat [INN]; HMR 1766; HMR-1766; 5-Chloro-2-((5-chloro-2-thienyl)sulfonylamino)-N-(4-(morpholin-4-ylsulfonyl)phenyl)benzamide; 5-Chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide; 5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-(4-morpholin-4-ylsulfonylphenyl)benzamide

Indication

Disease Entry	ICD 11	Status	REF
Neuropathic pain	8E43.0	Phase 2	[1]

Therapeutic Class

Analgesics

Cross-matching ID

PubChem CID: 213037
CAS Number: CAS 254877-67-3
TTD Drug ID: DM35KDA

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Atrial natriuretic peptide receptor A (NPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nesiritide	DMFOIA8	Congestive heart failure	BD10	Approved	[3]
Ularitide	DM90AG2	Acute heart failure	BD10-BD13	Phase 3	[4]
Cenderitide	DMCT8EY	Heart disease	BA41-BA42	Phase 2	[5]
PL-3994	DMHUCQS	Asthma	CA23	Phase 2	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Atrial natriuretic peptide receptor A (NPR1)	TTJME02	ANPRA_HUMAN	Activator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5141).
2	Pharma & Vaccines. Product Development Pipeline. April 29 2009.
3	The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure. Nephrol Dial Transplant. 2004 Feb;19(2):391-9.
4	Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
5	2011 Pipeline of Nile Therapeutics.
6	In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 April; 26(2): 229-238.