Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM39QWN)

Drug Name

ANS-6637 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Substance use disorder	6C4Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Mitochondrial aldehyde dehydrogenase (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALD-401	DM2U530	Cerebrovascular ischaemia	8B1Z	Phase 2	[2]
GS-6637	DMXG3T1	Substance use disorder	6C4Z	Phase 1	[3]
FP-045	DMV9FTH	Cardiovascular disease	BA00-BE2Z	Phase 1	[4]
Daidzin	DMFCMPS	N. A.	N. A.	Terminated	[5]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[5]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[5]
ISOFORMONENTIN	DM5CMA8	Discovery agent	N.A.	Investigative	[6]
prunetin	DMPD41Q	Discovery agent	N.A.	Investigative	[6]
CVT-10216	DMDH6PJ	Alcohol dependence	6C40.2	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mitochondrial aldehyde dehydrogenase (ALDH2)	TTFLN4T	ALDH2_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res. 2011 Dec 1;17(23):7265-72.
3	Clinical pipeline report, company report or official report of Gilead.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J Med Chem. 2008 Aug 14;51(15):4482-7.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2595).