Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3BEF7)

• Drug Name: Rimantadine isomer 2 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DM3BEF7

Molecule-Related Drug Atlas

Drug(s) Targeting Influenza M2 protein (Influ M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[2]
Rimantadine	DM5DWMU	Influenza A virus infection	1E30	Approved	[3]
TCN-032	DM9PVNJ	Influenza virus infection	1E30-1E32	Phase 2	[4]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[5]
Spiro[piperidine-2,2-adamantane]	DMWU9PV	Discovery agent	N.A.	Investigative	[1]
2-(1-adamantyl) piperidine	DM05OJD	Discovery agent	N.A.	Investigative	[1]
2-(1-adamantyl) pyrrolidine	DMMSFEU	Discovery agent	N.A.	Investigative	[1]
3-(2-adamantyl) pyrrolidine	DMS98WA	Discovery agent	N.A.	Investigative	[1]
Spiro[pyrrolidine-2,2-adamantane]	DMW48JD	Discovery agent	N.A.	Investigative	[1]
2-(1-adamantyl)-2-methyl-pyrrolidine	DMIGRMV	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza M2 protein (Influ M)	TTXT3PU	M2_I34A1	Inhibitor	[1]

References

• [1] Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
• [2] Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc. 2009 Jun 17;131(23):8066-76.
• [3] Antiviral resistance of influenza A (H3N2) strains isolated in northern Greece between 2004 and 2007. Euro Surveill. 2009 Jan 29;14(4). pii: 19104.
• [4] Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses. Proc Natl Acad Sci U S A. 2010 July 13; 107(28): 12658-12663.
• [5] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.