Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3D9XY)

Drug Name
interleukin-2, Roussel Uclaf Drug Info
Synonyms IL-2, Elf Sanofi; IL-2, Roussel Uclaf; RU-49637; U-49637; interleukin-2, Elf Sanofi
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DM3D9XY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aldesleukin DM4YMIS Acute myelogenous leukaemia 2A41 Approved [2]
Daclizumab DM6OZQV Aplastic anemia 3A70 Approved [3]
AIR-insulin DM8SYTE Diabetic complication 5A2Y Phase 3 [4]
TG-4010 DMWE3GB Bipolar disorder 6A60 Phase 2/3 [5]
BNZ-1 DM8JQZC Cutaneous T-cell lymphoma 2B01 Phase 2 [6]
IL-2/CD40L-expressing leukemia vaccine DMIHQ5G Chronic lymphocytic leukaemia 2A82.0 Phase 2 [7]
Carboxyamidotriazole orotate DMN5JCX Glioblastoma multiforme 2A00.0 Phase 2 [8]
Leuvectin DM5LQEI Melanoma 2C30 Phase 2 [9]
Human interleukin-2 DM0NJWG Renal cell carcinoma 2C90 Phase 2 [10]
L19-IL-2 fusion protein DMI2XP1 Lymphoma 2A80-2A86 Phase 2 [11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-2 (IL2) TTF89GD IL2_HUMAN Modulator [1]

References

1 Randomized study of recombinant interleukin-2 after autologous bone marrow transplantation for acute leukemia in first complete remission. Eur Cytokine Netw. 2000 Mar;11(1):91-8.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
4 The AIR inhaled insulin system: system components and pharmacokinetic/glucodynamic data. Diabetes Technol Ther. 2007 Jun;9 Suppl 1:S41-7.
5 A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J Thorac Oncol. 2008 Jul;3(7):735-44.
6 Clinical pipeline report, company report or official report of Bioniz Therapeutics.
7 Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and a... Blood. 2006 Feb 15;107(4):1332-41.
8 J Clin Oncol 32:5s, 2014 (suppl; abstr 2071).
9 Intratumoral interleukin 2 for renal-cell carcinoma by direct gene transfer of a plasmid DNA/DMRIE/DOPE lipid complex. World J Urol. 2000 Apr;18(2):152-6.
10 Clinical pipeline report, company report or official report of Immunservice.
11 National Cancer Institute Drug Dictionary (drug id 665656).