Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3IJQ5)

• Drug Name: MEDI5117 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DM3IJQ5

Molecule-Related Drug Atlas

Drug(s) Targeting Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Siltuximab	DMGEATB	Anemia	3A00-3A9Z	Approved	[3]
Sirukumab	DMK8AQP	Cutaneous lupus erythematosus	EB5Z	Phase 3	[4]
Olokizumab	DM4Z9QI	Rheumatoid arthritis	FA20	Phase 3	[5]
Ziltivekimab	DME841B	Heart failure	BD10-BD13	Phase 3	[6]
RG6179	DMO1VP9	uveitic macular edema	9B78	Phase 3	[7]
PF-04236921	DM826SW	Crohn disease	DD70	Phase 2	[4]
Clazakizumab	DM6ZOUV	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2 Trial	[4]
CDP-6038	DM3YB2C	Rheumatoid arthritis	FA20	Phase 2	[8]
ALD-518	DMPWSBL	Psoriatic arthritis	FA21	Phase 2	[8]
YSIL6	DM0K8U7	Crohn disease	DD70	Phase 2	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-6 (IL6)	TTT1V78	IL6_HUMAN	Modulator	[2]

References

• [1] ClinicalTrials.gov (NCT01559103) Study to Assess the Safety and Tolerability of MEDI5117 in Rheumatoid Arthritis Patients. U.S. National Institutes of Health.
• [2] Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics. J Mol Biol. 2011 Aug 26;411(4):791-807.
• [3] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study. Ann Rheum Dis. 2014 September; 73(9): 1607-1615.
• [6] IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet. 2021 May 29;397(10289):2060-2069.
• [7] Clinical pipeline report, company report or official report of Roche
• [8] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020380)