Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3KCL1)

Drug Name

4-(4-m-Tolylamino-phthalazin-1-yl)-benzamide Drug Info

Synonyms

CHEMBL196025; AC1LR1ZB; 4-(4-m-Tolylamino-phthalazin-1-yl)-benzamide; Oprea1_451204; MolPort-002-560-372; MolPort-000-703-859; ZINC1297754; BDBM50173029; STK846512; AKOS030511153; AKOS005626717; MCULE-6513504515; 4-(4-(m-tolylamino)phthalazin-1-yl)benzamide; AB00109646-01; 4-[4-(3-methylanilino)phthalazin-1-yl]benzamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1416247
TTD Drug ID: DM3KCL1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[2]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[3]
Regorafenib	DMHSY1I	Gastrointestinal stromal tumour	2B5B	Approved	[4]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[5]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[6]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[7]
Pazopanib HCl	DM6U9CQ	Renal cell carcinoma	2C90	Approved	[8]
Fruquintinib	DMHOSCQ	Colorectal cancer	2B91.Z	Approved	[9]
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[10]
Tivozanib	DMUKC5L	Renal cell carcinoma	2C90	Approved	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]

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References

1	Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4696-8.
2	Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40.
3	Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
6	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
7	A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
8	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
9	Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45.
10	Clinical pipeline report, company report or official report of Exelixis (2011).
11	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services