General Information of Drug (ID: DM3WAG6)

Drug Name
ADX71743 Drug Info
Synonyms ADX 71743; ADX-71743
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
53391766
TTD Drug ID
DM3WAG6

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [3]
[3H]quisqualate DMDQBTX Discovery agent N.A. Investigative [4]
L-CCG-I DMPZ8XH Discovery agent N.A. Investigative [3]
(1S,3R)-ACPD DM5DOAF Discovery agent N.A. Investigative [3]
(+)-MCPG DMG5QJB Discovery agent N.A. Investigative [3]
MAP4 DMUCE93 Discovery agent N.A. Investigative [3]
MPPG DMJHQ9T Discovery agent N.A. Investigative [3]
[3H]LY341495 DMGX0Y8 Discovery agent N.A. Investigative [3]
alpha-methylserine-O-phosphate DMCIH1X Discovery agent N.A. Investigative [3]
L-AP4 DMPJFGI Discovery agent N.A. Investigative [3]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Metabotropic glutamate receptor 7 (mGluR7) TT0I76D GRM7_HUMAN Modulator (allosteric modulator) [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6217).
2 ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.
3 Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
4 Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9.