Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM45MR0)

Drug Name

HIP-2B Drug Info

Indication

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Regenerating human pro-islet peptide (REG3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALF-5755	DMUA0XC	Liver failure	DB99.7	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Regenerating human pro-islet peptide (REG3A)	TTL4H8N	REG3A_HUMAN	Modulator	[3]

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References

1	ClinicalTrials.gov (NCT01933256) Study of Subcutaneous Doses of HIP2B in Subjects With Type 2 Diabetes Mellitus Treated With Metformin. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. Am J Pathol.1999 Nov;155(5):1525-33.
4	HIP/PAP prevents excitotoxic neuronal death and promotes plasticity. Ann Clin Transl Neurol. 2014 October; 1(10): 739-754.