Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM49MYE)

Drug Name

PF-877423 Drug Info

Synonyms

PF-877423; CHEMBL1095047; N-Adamantan-2-Yl-1-Ethyl-D-Prolinamide; SCHEMBL5157584; UJRJQNDIYCDCNX-BAPHQMLMSA-N; BDBM50317209; N-2-adamantyl-1-ethyl-D-prolinamide; (2R)-N-(adamantan-2-yl)-1-ethylpyrrolidine-2-carboxamide; (1S,2R)-N-(2-adamantyl)-1-ethyl-pyrrolidine-2-carboxamide; 1-ethyl-N-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]-D-prolinamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11601544
TTD Drug ID: DM49MYE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GLYCYRRHIZIN	DM8M2N3	Influenza virus infection	1E30-1E32	Phase 3	[2]
BVT.2733	DM6RUKX	Lupus	4A40	Phase 3	[3]
INCB13739	DMLQ3PO	Type-2 diabetes	5A11	Phase 2a	[4]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[5]
JTT-654	DM50M2R	Type-2 diabetes	5A11	Phase 2	[6]
RG-4929	DMT4QRD	Metabolic disorder	5C50-5D2Z	Phase 2	[6]
BMS-770767	DMTVGY7	Hypercholesterolaemia	5C80.0	Phase 2	[6]
UE-2343	DMIERPK	Alzheimer disease	8A20	Phase 2	[7]
AZD-4017	DML9M5S	Ocular hypertension	9C61.01	Phase 2	[6]
Xanamem	DM580GT	Alzheimer disease	8A20	Phase 1/2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]

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References

1	The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902.
2	Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. Bioorg Med Chem. 2009 Aug 1;17(15):5722-32.
3	Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003 Nov;144(11):4755-62.
4	Incyte's Selective Oral Inhibitor Of 11beta-HSD1 Demonstrates Improvements In Insulin Sensitivity And Lowers Cholesterol Levels In Type 2 Diabetics. Incyte. 2008.
5	11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.
6	New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	Selection and early clinical evaluation of the brain-penetrant 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor UE2343 (Xanamem?). Br J Pharmacol. 2017 Mar;174(5):396-408.