General Information of Drug (ID: DM4A92X)

Drug Name
MRL-953 Drug Info
Synonyms SDZ-MRL-953
Indication
Disease Entry ICD 11 Status REF
Immune System disease 4A01-4B41 Terminated [1]
Cross-matching ID
TTD Drug ID
DM4A92X

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GSK-1827771 DMA41JD Rheumatoid arthritis FA20 Phase 1 [3]
AMG 108 DMMUS8X Rheumatoid arthritis FA20 Discontinued in Phase 2 [4]
FR-133605 DMXWL0N Arthritis FA20 Terminated [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 1 receptor type 2 (IL1R2) TT51DEV IL1R2_HUMAN Agonist [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002036)
2 SDZ MRL 953, a lipid A analog as selective cytokine inducer. Prog Clin Biol Res. 1995;392:549-65.
3 WO patent application no. 2013,0077,63, Modulators of the nlrp3 inflammasome il-1ss pathway for the prevention and treatment of acne.
4 Clinical pipeline report, company report or official report of Amgen (2009).
5 Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83.