Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4B6H3)

Drug Name

L-isoleucine Drug Info

Synonyms

l-isoleucine; Isoleucine; 73-32-5; (2S,3S)-2-Amino-3-methylpentanoic acid; H-Ile-OH; (S)-Isoleucine; 2S,3S-Isoleucine; (S,S)-Isoleucine; 2-Amino-3-methylvaleric acid; erythro-L-Isoleucine; L-(+)-Isoleucine; L-Ile; alpha-Amino-beta-methylvaleric acid; 443-79-8; Isoleucine (VAN); Isoleucinum [Latin]; Isoleucina [Spanish]; Valeric acid, 2-amino-3-methyl-; Norvaline, 3-methyl-; L-Norvaline, 3-methyl-, erythro-; ISOLEUCINE, L-; Acetic acid, amino-sec-butyl-; Pentanoic acid, 2-amino-3-methyl-; CCRIS 5229; iso-leucine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6306
ChEBI ID: CHEBI:17191
CAS Number: CAS 443-79-8
TTD Drug ID: DM4B6H3
VARIDT Drug ID: DR00214

Molecule-Related Drug Atlas

Molecule Type:

DTP

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Transported By L-type amino acid transporter 3 (SLC43A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[2]
L-valine	DM68RPD	Discovery agent	N.A.	Investigative	[2]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Transported By L-type amino acid transporter 4 (SLC43A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Phenylalanine	DMQXI9F	Malnutrition	5B50-5B71	Approved	[3]
L-valine	DM68RPD	Discovery agent	N.A.	Investigative	[3]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
L-type amino acid transporter 3 (SLC43A1)	DTBMSWG	LAT3_HUMAN	Substrate	[2]
L-type amino acid transporter 4 (SLC43A2)	DTK02I1	LAT4_HUMAN	Substrate	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3311).
2	Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45.
3	Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542.