Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4EGV0)

Drug Name

Linaclotide Drug Info

Synonyms

Linaclotide (USAN)

Indication

Disease Entry	ICD 11	Status	REF
Irritable bowel syndrome	DD91.0	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Guanylyl cyclase C (GUCY2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MD-1100	DM4IAKR	Constipation	DD91.1	Approved	[3]
Plecanatide	DMKEX7O	Chronic idiopathic constipation	DC32	Approved	[4]
SP-333	DM2UKJV	Ulcerative colitis	DD71	Phase 2	[5]
MLN0264	DMI4E9K	Gastrointestinal cancer	2C11	Phase 2	[6]
PF-07062119	DME3BJL	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5017).
2	Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26.
3	Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	J Clin Oncol 31, 2013 (suppl; abstr TPS3646).
7	Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors. MAbs. Jan-Dec 2021;13(1):1850395.