Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4GZBI)

• Drug Name: Indolizine derivative 1 Drug Info
• Synonyms: PMID27718763-Compound-5
• Cross-matching ID:
  PubChem CID: 71679723
  TTD Drug ID: DM4GZBI

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[2]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[2]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[2]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[2]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[2]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[2]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[2]
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[3]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[4]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Platelet-activating factor acetylhydrolase (PLA2G7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rilapladib	DMB9861	Arteriosclerosis	BD40	Phase 1	[6]
GSK2647544	DM3KARJ	Alzheimer disease	8A20	Phase 1	[7]
Bicyclic pyrimidine derivative 2	DMJP16K	N. A.	N. A.	Patented	[1]
RPAF-AH	DMOVJ60	Sepsis	1G40-1G41	Discontinued in Phase 3	[8]
GSK568859	DM6E84O	Arteriosclerosis	BD40	Discontinued in Phase 1	[7]
Goxalapladib	DMSGUY9	Arteriosclerosis	BD40	Discontinued in Phase 1	[9]
(1r)-1,2,2-trimethylpropyl (r)-methylphosphinate	DMVE34H	Discovery agent	N.A.	Investigative	[10]
Benzaldehyde O-benzoyloxime	DMB7DFT	Discovery agent	N.A.	Investigative	[11]
(E)-(thiophen-2-ylmethylidene)amino benzoate	DMHSJAT	Discovery agent	N.A.	Investigative	[12]
3,4-difluorobenzaldehyde O-benzoyloxime	DMFV3Y9	Discovery agent	N.A.	Investigative	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]
Platelet-activating factor acetylhydrolase (PLA2G7)	TTDNFMT	PAFA_HUMAN	Inhibitor	[1]

References

• [1] Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
• [2] 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
• [3] Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
• [4] Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
• [5] Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
• [6] Phospholipase A2 inhibitors. Curr Opin Lipidol. 2009 Aug;20(4):327-32.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1432).
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006777)
• [9] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020582)
• [10] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [11] Potent inhibitors of lipoprotein-associated phospholipase A(2): benzaldehyde O-heterocycle-4-carbonyloxime. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5576-9.
• [12] (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1525-7.