Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4LOD0)

Drug Name

Alglucosidase alfa Drug Info

Synonyms

Lumizyme (TN); Myozyme (TN)

Indication

Disease Entry	ICD 11	Status	REF
Pompe disease	5C51.3	Approved	[1]

Therapeutic Class

Enzyme Replacement Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Mannose-6-phosphate receptor (M6PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-D-Mannose-6-Phosphate	DM3NCM1	Discovery agent	N.A.	Investigative	[3]
1-3 Sugar Ring of Pentamannosyl 6-Phosphate	DMRO1IU	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mannose-6-phosphate receptor (M6PR)	TT95ICL	MPRD_HUMAN	Binder	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7561).
2	Early treatment with alglucosidase alpha prolongs long-term survival of infants with Pompe disease. Pediatr Res. 2009 Sep;66(3):329-35.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.