Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4YIWK)

Drug Name

VBY-129 Drug Info

Synonyms

Cathepsin S inhibitor (oral, psoriasis), Virobay

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Phase 1	[1]
Crohn disease	DD70	Phase 1	[2]
Neuropathic pain	8E43.0	Phase 1	[3]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Cathepsin S (CTSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RG7625	DMDGPKS	Autoimmune disease	4A40-4A45	Phase 2	[2]
SAR-114137	DMZ1XR5	Pain	MG30-MG3Z	Phase 1	[5]
VBY- 891	DMTKPH4	Autoimmune diabetes	5A10	Phase 1	[6]
VBY- 036	DMULRYC	Neuropathic pain	8E43.0	Phase 1	[7]
PMID27998201-Compound-12	DM8QZNC	Bone cancer	2B5Z	Patented	[8]
PMID27998201-Compound-5	DMVZ0ND	Chronic obstructive pulmonary disease	CA22	Patented	[8]
PMID27998201-Compound-9	DM1JOZN	Rheumatoid arthritis	FA20	Patented	[8]
PMID25399719-Compound-17	DMRXKJZ	N. A.	N. A.	Patented	[9]
PMID27998201-Compound-17	DMAZVHJ	Hair loss	ED70	Patented	[8]
Phenylalanine derivative 1	DMVYP8K	Glioma	2A00.0	Patented	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of ViroBay.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of ViroBay.
5	From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).
7	Clinical pipeline report, company report or official report of ViroBay.
8	Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
9	An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.