Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM51GZS)

Drug Name

HR325 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Dihydroorotate dehydrogenase (DHODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[3]
Vidofludimus	DM0POWG	Inflammatory bowel disease	DD72	Phase 2	[4]
BREQUINAR	DMKGM42	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[5]
BAY2402234	DMRL6W5	Myeloid leukaemia	2B33.1	Phase 1	[6]
LAS-186323	DMV80DP	Multiple sclerosis	8A40	Phase 1	[7]
FK778	DMH6QAI	Kidney/heart transplant rejection	NE84	Discontinued in Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydroorotate dehydrogenase (DHODH)	TTLVP78	PYRD_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005016)
2	In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42.
3	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4	Company report (4SC)
5	DOI: 10.1203/00006450-198807000-00137
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Clinical pipeline report, company report or official report of Aslanpharma.
8	Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9.