Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTLVP78)

• DTT Name: Dihydroorotate dehydrogenase (DHODH)
• Synonyms: Dihydroorotate oxidase; Dihydroorotate dehydrogenase (quinone), mitochondrial; DHOdehase; DHODH
• Gene Name: DHODH
• DTT Type: Successful target; [1]
• BioChemical Class: CH-CH donor oxidoreductase
• UniProt ID: PYRD_HUMAN
• TTD ID: T61400
• EC Number: EC 1.3.5.2
• Sequence:
  MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
  FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
  TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
  LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
  DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
  GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
  WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
• Function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
• KEGG Pathway:
  Pyrimidine metabolism (hsa00240)
  Metabolic pathways (hsa01100)
• Reactome Pathway: Pyrimidine biosynthesis (R-HSA-500753)

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[1]

4 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BREQUINAR	DMKGM42	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[2]
Vidofludimus	DM0POWG	Inflammatory bowel disease	DD72	Phase 2	[3]
BAY2402234	DMRL6W5	Myeloid leukaemia	2B33.1	Phase 1	[4]
LAS-186323	DMV80DP	Multiple sclerosis	8A40	Phase 1	[5]

2 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FK778	DMH6QAI	Kidney/heart transplant rejection	NE84	Discontinued in Phase 2	[6]
HR325	DM51GZS	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[7]

References

• [1] Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
• [2] DOI: 10.1203/00006450-198807000-00137
• [3] Company report (4SC)
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Clinical pipeline report, company report or official report of Aslanpharma.
• [6] Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9.
• [7] In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42.