Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM54EFD)

Drug Name
Terpyridineplatinum(II) complexe 3 Drug Info
Synonyms PMID27977313-Compound-3
Cross-matching ID
TTD Drug ID
DM54EFD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutathione reductase (GR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [2]
Golden phosphorous acetyletic compound 2 DMYJ15A N. A. N. A. Patented [1]
Terpyridineplatinum(II) complexe 4 DMOV86T N. A. N. A. Patented [1]
Golden phosphorous acetyletic compound 1 DMVAKUI N. A. N. A. Patented [1]
Acyl oxymethyl acrylamide ester derivative 1 DMXTUE1 N. A. N. A. Patented [1]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [3]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [3]
3-Sulfinoalanine DMILTRN N. A. N. A. Investigative [3]
1-(2'-chlorophenyl)penta-1,4-dien-3-one DMKTZSY Discovery agent N.A. Investigative [4]
Trans-(R(S))-2-Hydroxy-1-phenylethyl nitrate DMXC98D Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cytoplasmic thioredoxin reductase (TXNRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fotemustine DMV62ED Solid tumour/cancer 2A00-2F9Z Approved [3]
Spermidine DMVJNFI Plaque psoriasis EA90.0 Phase 3 [3]
Golden phosphorous acetyletic compound 2 DMYJ15A N. A. N. A. Patented [1]
Terpyridineplatinum(II) complexe 4 DMOV86T N. A. N. A. Patented [1]
Golden phosphorous acetyletic compound 1 DMVAKUI N. A. N. A. Patented [1]
Acyl oxymethyl acrylamide ester derivative 1 DMXTUE1 N. A. N. A. Patented [1]
PMID27977313-Compound-18 DMIA3GH N. A. N. A. Patented [1]
Triazole gold complexe 1 DMCWES7 N. A. N. A. Patented [1]
4-aryl quinol derivative 2 DM7TW5Z N. A. N. A. Patented [1]
PMID27977313-Compound-46 DMGF04T N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cytoplasmic thioredoxin reductase (TXNRD1) TTR7UJ3 TRXR1_HUMAN Inhibitor [1]
Glutathione reductase (GR) TTEP6RV GSHR_HUMAN Inhibitor [1]

References

1 Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
2 The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401.
3 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4 Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.
5 In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3.