Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM54M6C)

Drug Name

2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid Drug Info

Synonyms

CHEMBL77981; 2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid; SCHEMBL7166052; JSJQNYIFLKCXRE-UHFFFAOYSA-N; ZINC13809288; BDBM50090679; 2-(2,5-Dichloroanilino)benzeneacetic acid; 2-[(2,5-dichlorophenyl)amino]phenylacetic acid; [2-(2,5-Dichloro-phenylamino)-phenyl]-acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 14076674
TTD Drug ID: DM54M6C

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Interleukin-8 (IL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1]
ABX-IL8	DMCZFMS	Melanoma	2C30	Phase 2	[2]
BMS-986253	DM42B0C	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[3]
MDX-018	DML5FX2	Autoimmune diabetes	5A10	Phase 1	[4]
R-ketoprofen	DMHSUQ1	N. A.	N. A.	Discontinued in Phase 2	[1]
2-(2-(2-chlorophenylamino)phenyl)acetic acid	DMPLV3A	Discovery agent	N.A.	Investigative	[1]
2-(2-(2-fluorophenylamino)phenyl)acetic acid	DMVQ68F	Discovery agent	N.A.	Investigative	[1]
2-(2-(2-chlorophenoxy)phenyl)acetic acid	DMBP1TQ	Discovery agent	N.A.	Investigative	[1]
2-(2-(2-fluorophenoxy)phenyl)acetic acid	DMDSUR2	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-8 (IL8)	TTCTE1G	IL8_HUMAN	Inhibitor	[1]

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References

1	Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30.
2	Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul;161(1):125-34.
3	Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors. J Immunother Cancer. 2019 Sep 5;7(1):240.
4	Company report (Genmab)