Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5CMA8)

Drug Name

ISOFORMONENTIN Drug Info

Synonyms

isoformononetin; 486-63-5; 3-(4-Hydroxyphenyl)-7-methoxy-4H-chromen-4-one; 4'-HYDROXY-7-METHOXYISOFLAVONE; 7-methoxy-4'-hydroxyisoflavone; CHEBI:29608; LNIQZRIHAMVRJA-UHFFFAOYSA-N; HMO; 4H-1-Benzopyran-4-one, 3-(4-hydroxyphenyl)-7-methoxy-; ISOFORMONENTIN; 7-O-methyldaidzein; AC1L1GNQ; SCHEMBL73338; CTK8C3880; DTXSID40274405; ZINC968077; LMPK12050039; 6634AB; ANW-70750; AKOS016007909; DB04202; CCG-214134; AJ-24572; AX8239272; 4,(S); 3-(4-hydroxyphenyl)-7-methoxychromen-4-one; C12125; SR-05000002516

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3764
ChEBI ID: CHEBI:29608
CAS Number: CAS 486-63-5
TTD Drug ID: DM5CMA8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Mitochondrial aldehyde dehydrogenase (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALD-401	DM2U530	Cerebrovascular ischaemia	8B1Z	Phase 2	[2]
GS-6637	DMXG3T1	Substance use disorder	6C4Z	Phase 1	[3]
ANS-6637	DM39QWN	Substance use disorder	6C4Z	Phase 1	[4]
FP-045	DMV9FTH	Cardiovascular disease	BA00-BE2Z	Phase 1	[5]
Daidzin	DMFCMPS	N. A.	N. A.	Terminated	[6]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[6]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[6]
prunetin	DMPD41Q	Discovery agent	N.A.	Investigative	[1]
CVT-10216	DMDH6PJ	Alcohol dependence	6C40.2	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mitochondrial aldehyde dehydrogenase (ALDH2)	TTFLN4T	ALDH2_HUMAN	Inhibitor	[1]

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References

1	Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J Med Chem. 2008 Aug 14;51(15):4482-7.
2	A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res. 2011 Dec 1;17(23):7265-72.
3	Clinical pipeline report, company report or official report of Gilead.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2595).