Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5ZTJL)

Drug Name

Calmidazolium Drug Info

Synonyms

Calmidazolium ion; 95013-41-5; CHEBI:75400; R24571; MLS002172477; CHEMBL1208858; SMR001254103; SR-01000075486; Probes1_000251; Probes2_000292; Lopac0_000272; methoxy]ethyl]-1H-imidazolium; cid_644274; SCHEMBL8224791; CHEMBL1229168; BDBM76238; DTXSID30915173; BDBM50323389; HSCI1_000319; CCG-204367; NCGC00015233-02; NCGC00015233-03; NCGC00015233-04; NCGC00015233-08; NCGC00162113-01; NCGC00167775-01; 1-(Bis(4-chlorophenyl)methyl)-3-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-1H-imidazolium; 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazol-3-ium; 1-[bis(4-chlorophenyl)methyl]-3-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazol-3-ium; 1H-Imidazolium, 1-(bis(4-chlorophenyl)methyl)-3-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-; SR-01000075486-7; SR-01000075486-8; BRD-A26199074-003-01-2; Q27145276; 3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl); 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazol-3-ium;chloride; 1-[Bis(4-chlorophenyl)methyl]-3-{2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl}-1H-imidazol-3-ium

Indication

Disease Entry	ICD 11	Status	REF
Huntington disease	8A01.10	Investigative	[1]

Cross-matching ID

PubChem CID: 2531
ChEBI ID: CHEBI:75400
CAS Number: CAS 95013-41-5
TTD Drug ID: DM5ZTJL

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Calmodulin (CALM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halofantrine	DMOMK1V	Malaria	1F40-1F45	Approved	[3]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[4]
Aprindine	DMBXWU8	Cardiac arrhythmias	BC9Z	Approved	[5]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[6]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[6]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[7]
Cacodylate Ion	DMK4XLD	Discovery agent	N.A.	Investigative	[6]
2-Methyl-2-Propanol	DMHM5GJ	Discovery agent	N.A.	Investigative	[6]
N-Trimethyllysine	DMZQXLS	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calmodulin (CALM)	TTV3NH6	CALM1_HUMAN; CALM2_HUMAN; CALM3_HUMAN	Inhibitor	[2]

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References

1	Calmidazolium Chloride and Its Complex with Serum Albumin Prevent Huntingtin Exon1 Aggregation. Mol Pharm. 2018 Aug 6;15(8):3356-3368.
2	Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med. 2003 Aug;69(8):692-5.
5	Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):151-6.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.