Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM65XZJ)

Drug Name

5-deoxy-5-phosphono-D-arabinonate Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Phosphogluconate dehydrogenase (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GHRP-2	DMKGH0R	Growth hormone deficiency	5A61.3	Approved	[2]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[3]
4-phospho-D-erythronate	DMW4KXQ	Discovery agent	N.A.	Investigative	[4]
6-Phosphogluconic Acid	DMB1QCY	Discovery agent	N.A.	Investigative	[5]
(2R)-2-Methyl-4,5-dideoxy	DM3K2TI	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphogluconate dehydrogenase (PGD)	TTZ3IFB	6PGD_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14.
2	Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62.
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.