Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTZ3IFB)

• DTT Name: Phosphogluconate dehydrogenase (PGD)
• Synonyms: PGDH; 6PGDH; 6-phosphogluconate dehydrogenase, decarboxylating; 6-phosphogluconate dehydrogenase
• Gene Name: PGD
• DTT Type: Successful target; [1]
• BioChemical Class: CH-OH donor oxidoreductase
• UniProt ID: 6PGD_HUMAN
• TTD ID: T76497
• EC Number: EC 1.1.1.44
• Sequence:
  MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
  MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG
  ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG
  HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL
  KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA
  SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL
  MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM
  PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS
  YNA
• Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
• KEGG Pathway:
  Pentose phosphate pathway (hsa00030)
  Glutathione metabolism (hsa00480)
  Metabolic pathways (hsa01100)
  Biosynthesis of antibiotics (hsa01130)
  Carbon metabolism (hsa01200)
• Reactome Pathway:
  Nuclear events mediated by NFE2L2 (R-HSA-9759194)
  Pentose phosphate pathway (R-HSA-71336)
• BioCyc Pathway: MetaCyc:HS06949-MON

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GHRP-2	DMKGH0R	Growth hormone deficiency	5A61.3	Approved	[1]

5 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2R)-2-Methyl-4,5-dideoxy	DM3K2TI	Discovery agent	N.A.	Investigative	[1]
4-phospho-D-erythronate	DMW4KXQ	Discovery agent	N.A.	Investigative	[2]
5-deoxy-5-phosphono-D-arabinonate	DM65XZJ	Discovery agent	N.A.	Investigative	[3]
6-Phosphogluconic Acid	DMB1QCY	Discovery agent	N.A.	Investigative	[4]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[5]

References

• [1] Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14.
• [2] Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62.
• [3] Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.