Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6BJEW)

Drug Name
Urea and carbamate bioisostere derivative 13 Drug Info
Synonyms PMID28074661-Compound-US20056867299c40
Cross-matching ID
TTD Drug ID
DM6BJEW

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [2]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [3]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [4]
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [5]
Mizoribine DMW6F0S Transplant rejection NE84 Approved [4]
Viramidine DMJFNR9 Hepatitis C virus infection 1E51.1 Phase 3 [6]
VX-944 DME321B Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
VX-148 DML32R8 Psoriasis vulgaris EA90 Patented [7]
PMID28074661-Compound-US20100022547C81 DMM9E1U N. A. N. A. Patented [1]
PMID28074661-Compound-US20120264760C80 DM75QVW N. A. N. A. Patented [1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) TTL7C8Q IMDH1_HUMAN Inhibitor [1]

References

1 Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
2 Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67.
3 Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13.
4 VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37.
5 In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30.
6 Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
7 Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.