Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6JKL7)

Drug Name

XMetS Drug Info

Synonyms

Insulin receptor sensitizing antibody (diabetes), XOMA

Indication

Disease Entry	ICD 11	Status	REF
Non-insulin dependent diabetes	5A11	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[2]
Human neutral insulin	DMA5OBU	Diabetic complication	5A2Y	Approved	[3]
Insulin Lyspro recombinant	DM5XHVR	Diabetic complication	5A2Y	Approved	[3]
Insulin, porcine	DMO95XI	Diabetic complication	5A2Y	Approved	[4]
Insulin recombinant	DMYVP5G	Diabetic complication	5A2Y	Approved	[3]
Metformin arginine-hemisuccinimide	DMTPAM3	Type-2 diabetes	5A11	Approved	[5]
Insulin-lispro	DM4O90W	Diabetic complication	5A2Y	Approved	[6]
Insulin-glulisine	DMQI0FU	Diabetic complication	5A2Y	Approved	[7]
Ryzodeq	DMOFP18	Type-2 diabetes	5A11	Approved	[1]
NN5401	DM0QV27	Diabetic complication	5A2Y	Phase 3	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800).
2	New drugs for type 2 diabetes mellitus: what is their place in therapy Drugs. 2008;68(15):2131-62.
3	Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
4	Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9.
5	Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 1;67(11):2081-91.
6	Hope for insulin mimetic oral antidiabetic drugs. Eur J Endocrinol. 1999 Dec;141(6):561-2.
7	Insulin glulisine: a review of its use in the management of diabetes mellitus. Drugs. 2009;69(8):1035-57.