Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6QFSV)

Drug Name

Erdosteine Drug Info

Synonyms

Asdigan; Biopulmin; Dostin; Dostol; Drupsan; Ectrin; Edirel; Erdomed; Erdopect; Erdos; Erdotin; Esteclin; Fluidasa; Flusten; Mucoflux; Mucofor; Mucotec; Mucothera; Mukial; Secresolv; Theovix; Tusselin; Vectrine; KW-9144; RV-144

Indication

Disease Entry	ICD 11	Status	REF
Bronchitis	CA20	Approved	[1]

Cross-matching ID

PubChem CID: 65632
ChEBI ID: CHEBI:135014
CAS Number: CAS 84611-23-4
TTD Drug ID: DM6QFSV

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Pancreatic elastase 1 (CELA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[2]
Sivelestat	DM6BZCV	Crohn disease	DD70	Phase 3	[3]
Mdl 101,146	DMRSOBG	Inflammation	1A00-CA43.1	Terminated	[4]
WIN-63759	DMRV48P	Emphysema	CA21	Terminated	[5]
SSR-69071	DMWL4MI	Chronic obstructive pulmonary disease	CA22	Terminated	[6]
SYN-1134	DMG2SQM	Cystic fibrosis	CA25	Terminated	[7]
PBI-1101	DMWD1RC	Inflammation	1A00-CA43.1	Terminated	[8]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[4]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[9]
Dimethylformamide	DML6O4N	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pancreatic elastase 1 (CELA1)	TT3NKIB	CELA1_HUMAN	Modulator	[1]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Elastase inhibitors. J Soc Biol. 2001;195(2):143-50.
3	Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome... Shock. 2010 Jan;33(1):14-8.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Biological activity of WIN 63759, an orally bioavailable inhibitor of human neutrophil elastase. Drug Development Research Volume 34, Issue 3, pages 306-316, March 1995.
6	Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011 Aug 19;286(33):28889-901.
7	EP patent application no. 1292314, Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of glycosaminoglycans.
8	CN patent application no. 1813706, Use of elastic protease inhibitor for preparing medicine for protecting cerebral hemorrhage.
9	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
10	Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 1988 May;108(5):680-6.