Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6TFPY)

• Drug Name: PMID24900237C15 Drug Info
• Synonyms: 1022957-12-5; GTPL8220; BDBM50385590; KB-75520

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 25229528
  TTD Drug ID: DM6TFPY

Molecule-Related Drug Atlas

Drug(s) Targeting ALK tyrosine kinase receptor (ALK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[2]
Lorlatinib	DMICDLV	Non-small-cell lung cancer	2C25.Y	Approved	[3]
Entrectinib	DMMPTLH	Non-small-cell lung cancer	2C25	Approved	[4]
Brigatinib	DM7W94S	Anaplastic large cell lymphoma	2A90.A	Approved	[5]
Repotrectinib	DM9FB2T	Non-small-cell lung cancer	2C25	Approved	[6]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[7]
Alectinib	DMP1I6Y	Lung cancer	2C25.0	Approved	[8]
Ensartinib	DMIKDCQ	Non-small-cell lung cancer	2C25.Y	Phase 3	[6]
PF-06463922	DMKM7EW	Non-small-cell lung cancer	2C25.Y	Phase 2	[9]
AP26113	DMYBQEF	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]

Drug(s) Targeting Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[11]
Human neutral insulin	DMA5OBU	Diabetic complication	5A2Y	Approved	[12]
Insulin Lyspro recombinant	DM5XHVR	Diabetic complication	5A2Y	Approved	[12]
Insulin, porcine	DMO95XI	Diabetic complication	5A2Y	Approved	[13]
Insulin recombinant	DMYVP5G	Diabetic complication	5A2Y	Approved	[12]
Metformin arginine-hemisuccinimide	DMTPAM3	Type-2 diabetes	5A11	Approved	[14]
Insulin-lispro	DM4O90W	Diabetic complication	5A2Y	Approved	[15]
Insulin-glulisine	DMQI0FU	Diabetic complication	5A2Y	Approved	[16]
Ryzodeq	DMOFP18	Type-2 diabetes	5A11	Approved	[17]
NN5401	DM0QV27	Diabetic complication	5A2Y	Phase 3	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ALK tyrosine kinase receptor (ALK)	TTPMQSO	ALK_HUMAN	Inhibitor	[1]
Insulin receptor (INSR)	TTCBFJO	INSR_HUMAN	Inhibitor	[1]
Unc-51 like kinase 3 (ULK3)	TTYENHQ	ULK3_HUMAN	Inhibitor	[1]

References

• [1] Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity. ACS Med Chem Lett. 2010 Sep 1;1(9):493-8.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [5] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [6] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7397).
• [8] CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011 May 17;19(5):679-90.
• [9] PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models. Cancer Cell. 2015 Jul 13;28(1):70-81.
• [10] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [11] New drugs for type 2 diabetes mellitus: what is their place in therapy Drugs. 2008;68(15):2131-62.
• [12] Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
• [13] Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9.
• [14] Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 1;67(11):2081-91.
• [15] Hope for insulin mimetic oral antidiabetic drugs. Eur J Endocrinol. 1999 Dec;141(6):561-2.
• [16] Insulin glulisine: a review of its use in the management of diabetes mellitus. Drugs. 2009;69(8):1035-57.
• [17] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800).