Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6XC8H)

Drug Name

MSC110 Drug Info

Synonyms

Lacnotuzumab

Indication

Disease Entry	ICD 11	Status	REF
Pigmented villonodular synovitis	FA27.1	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RG7155	DM8JMNL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Emactuzumab	DM4W7Z0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PLX73086	DMED2WN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Macrophage colony-stimulating factor 1 (CSF1)	TT0IQER	CSF1_HUMAN	Inhibitor	[1]

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References

1	Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)