Details of the Drug-Related molecule(s) Interaction Atlas

BK3 Drug Info

CHEMBL1231372; MMV676182; 3-(Naphthalen-1-Ylmethyl)-1-(Piperidin-4-Ylmethyl)-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine; BK3; SCHEMBL12437018; BDBM50345712; 3-(1-naphthylmethyl)-1-(4-piperidylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine

Cross-matching ID

PubChem CID

46398830

TTD Drug ID

DM6YQO3

General Information of Drug (ID: DM6YQO3)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Hematopoietic cell kinase (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doramapimod	DM6BU7N	Inflammatory bowel disease	DD72	Patented	[2]
3-(6-allyloxy-2-naphthyl)-1-(4-piperidylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine	DM0DYAU	N. A.	N. A.	Patented	[1]
Unii-I92MU0V408	DMUD7H8	N. A.	N. A.	Patented	[2]
US8933228, 3	DMPNCOL	N. A.	N. A.	Patented	[2]
SB19065	DM2MQD0	N. A.	N. A.	Patented	[3]
US9108950, 1	DMPT2ZS	N. A.	N. A.	Patented	[4]
US8933228, Ref 2	DMKEX51	N. A.	N. A.	Patented	[5]
BK7	DMQD4X2	N. A.	N. A.	Patented	[1]
PP121	DMU8KTO	Discovery agent	N.A.	Investigative	[6]
PMID15546730C2	DMOPUIH	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hematopoietic cell kinase (HCK)	TT42OGM	HCK_HUMAN	Inhibitor	[1]

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References

1	Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases. US9765037.
2	Respiratory formulations and compounds for use therein. US8933228.
3	Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same. US9062066.
4	1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as p38 MAP kinase inhibitors. US9108950.
5	1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP knase inhibitors. US9724347.
6	Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.
7	Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6.