Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6Z7AD)

Drug Name
CAR-T cells targeting CD80/86 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM6Z7AD

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Activation B7-1 antigen (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Abatacept DMSA8RU Alopecia areata ED70.2 Approved [2]
RhuDex DMGM1IR Rheumatoid arthritis FA20 Phase 2a [3]
HS-110 DML4RCG Non-small-cell lung cancer 2C25.Y Phase 2 [4]
Galiximab DMTXCUS Lymphoma 2A80-2A86 Phase 2 [5]
MAXY-4 DMMP7XG Autoimmune diabetes 5A10 Phase 1 [6]
Tolerimab DMZKIE0 Transplant rejection NE84 Terminated [7]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Activation B7-1 antigen (CD80) TTFZDNP CD80_HUMAN CAR-T-Cell-Therapy [1]

References

1 ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers
2 Selective modulation of T-cell co-stimulation: a novel mode of action for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2009 May-Jun;27(3):510-8.
3 A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.
4 Clinical pipeline report, company report or official report of Heat Biologics.
5 Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma. J Clin Oncol. 2005 Jul 1;23(19):4390-8.
6 Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3.
7 US patent application no. 2004,0171,123, Albumin fusion proteins.