Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6ZPLQ)

Drug Name

Novolimus Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Artery stenosis	BD52	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Serine/threonine-protein kinase mTOR (mTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[3]
Temsirolimus	DMS104F	Renal cell carcinoma	2C90	Approved	[4]
PF-04449913	DMSB068	Chronic myelomonocytic leukaemia	2A40	Approved	[5]
Everolimus	DM8X2EH	Advanced cancer	2A00-2F9Z	Approved	[6]
Zotarolimus	DMRMCXW	Solid tumour/cancer	2A00-2F9Z	Approved	[7]
Ridaforolimus	DMLHEU7	Sarcoma	2A60-2C35	Phase 3	[8]
AZD2014	DMOEARH	Solid tumour/cancer	2A00-2F9Z	Phase 2	[9]
MM-141	DM2RJ4D	Pancreatic cancer	2C10	Phase 2	[10]
PQR309	DMMCYZ8	Squamous head and neck cell carcinom	2D60.0	Phase 2	[2]
Salirasib	DMRSU4X	Lung cancer	2C25.0	Phase 2	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serine/threonine-protein kinase mTOR (mTOR)	TTCJG29	MTOR_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	Clinical pipeline report, company report or official report of Elixir.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109).
3	Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
4	Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci. 2014 Nov;35(11):604-20.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Mammalian target of rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma. Gan To Kagaku Ryoho. 2009 Jul;36(7):1076-9.
7	Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep. 2008 Jun;25(3):475-516.
8	A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8.
9	Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014. Biochem Biophys Res Commun. 2014 Jan 10;443(2):406-12.
10	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)