Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM71BFM)

Drug Name

DNA-Ad Drug Info

Synonyms

DNA-prime/adenovirus (Ad5)-boost CSP-and AMA1-encoding malaria vaccine (Biojector2000, intramuscular), US NavalMedical Research Center (NMRC)/Bioject/Vical/GenVec

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Phase 1/2	[1]

Cross-matching ID

TTD Drug ID: DM71BFM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Plasmodium Apical membrane protein (Malaria AMA-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AdCh63 AMA1	DMEGPSW	Malaria	1F40-1F45	Phase 1/2	[3]
PfAMA-1	DMLDZX1	Malaria	1F40-1F45	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Apical membrane protein (Malaria AMA-1)	TTQZW34	AMA1_PLAFF	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT00870987) Clinical Trial for Malaria Vaccines to Test for Safety, Immune Response and Protection Against Malaria. U.S. National Institutes of Health.
2	Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes. PLoS One. 2014 Sep 11;9(9):e106241.
3	ClinicalTrials.gov (NCT01142765) Study to Assess Efficacy of New Malaria Vaccine Candidates AdCh63 AMA1, MVA AMA1, AdCh63 MSP1, MVA MSP1, AdCh63 ME-TRAP & MVA ME-TRAP. U.S. National Institutes of Health.
4	Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite devel... J Cell Sci. 2003 Sep 15;116(Pt 18):3825-34.