Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM753H8)

Drug Name

EB8018 Drug Info

Synonyms

Sibofimloc; 1616113-45-1; Antibiotic-202; VRT-1353385; UNII-00OF00QZC4; 1-[2,7-Bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone; 1-[2,7-bis({2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl})spiro[fluorene-9,4'-piperidine]-1'-yl]ethan-1-one; 1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone; Sibofimloc [INN]; Sibofimloc [USAN]; Sibofimloc (USAN/INN); CHEMBL4594305; SCHEMBL15836795; EX-A750; Antibiotic-202;VRT-1353385; MFCD28144726; WHO 10950; ZINC209678340; ACN-052475; CS-5487; DA-43714; HY-12820; B5896; D11825; J-690221; 1-(2,7-Bis(2,6-anhydro-7,8-dideoxy-D-glycero-D-manno-oct-7-ynitol-8-yl)spiro(fluorene-9,4'-piperidin)-1'-yl)ethan-1-one; 1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4a?piperidine]-1a?yl]ethanone; 8,8'-(1'-Acetylspiro(9H-fluorene-9,4'-piperidine)-2,7-diyl)bis(2,6-anhydro-7,8-dideoxy-D-glycero-D-manno-oct-7-ynitol); D-Glycero-D-manno-oct-7-ynitol, 8,8'-(1'-acetylspiro(9H-fluorene-9,4'-piperidine)-2,7-diyl)bis(2,6-anhydro-7,8-dideoxy-

Indication

Disease Entry	ICD 11	Status	REF
Crohn disease	DD70	Phase 2	[1]

Cross-matching ID

PubChem CID: 76684239
CAS Number: CAS 1616113-45-1
TTD Drug ID: DM753H8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Bacterial Fimbrin D-mannose adhesin (Bact FimH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK3882347	DM1DU20	Urinary tract infection	GC08	Phase 1	[3]
GSK3882347	DM1DU20	Urinary tract infection	GC08	Phase 1	[4]
Biaryl mannoside derivative 24	DMF5TB4	Crohn disease	DD70	Patented	[5]
PMID26651364-Compound-5	DMH7XL3	Crohn disease	DD70	Patented	[5]
PMID26651364-Compound-116	DMJ3201	Crohn disease	DD70	Patented	[5]
Biaryl mannoside derivative 8	DMWF2VG	Crohn disease	DD70	Patented	[5]
Beta-cyclodextrin conjugate derivative 3	DMQJF4P	Crohn disease	DD70	Patented	[5]
PMID26651364-Compound-109	DM01IWV	Crohn disease	DD70	Patented	[5]
PMID26651364-Compound-114	DM5GHJA	Crohn disease	DD70	Patented	[5]
Biphenyl mannoside derivative 6	DM93VEB	Crohn disease	DD70	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Fimbrin D-mannose adhesin (Bact FimH)	TTTCRU2	FIMH_ECOLI	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT03943446) TAK-018 for Prevention of the Recurrence of Postoperative Crohn's Disease (CD). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Enterome Biosciences.
3	Clinical pipeline report, company report or official report of Fimbrion Therapeutics
4	Clinical pipeline report, company report or official report of GlaxoSmithKline
5	Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97.