Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM76GRQ)

Drug Name

Farampator Drug Info

Synonyms

CX 691; CX-691; Farampator (USAN/INN); 1-(Benzofurazan-5-ylcarbonyl)piperidine; 2,1,3-benzoxadiazol-5-yl(piperidin-1-yl)methanone

Indication

Disease Entry	ICD 11	Status	REF
Major depressive disorder	6A70.3	Discontinued in Phase 1	[1]
Schizophrenia	6A20	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 4118151
CAS Number: CAS 211735-76-1
TTD Drug ID: DM76GRQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glutamate receptor AMPA 1 (GRIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[3]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[4]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[5]
GYKI-52466	DM3YG5P	Alzheimer disease	8A20	Terminated	[6]
GYKI-53655	DMC0JN8	N. A.	N. A.	Terminated	[7]
Zonampanel	DM70HZD	N. A.	N. A.	Terminated	[5]
SORETOLIDE	DMTDLHG	Convulsion	8A68.Z	Terminated	[8]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[9]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[10]
RPR-118723	DMLDWCB	Discovery agent	N.A.	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Binder	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012259)
2	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
3	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4	Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26.
5	Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11.
6	New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70.
7	Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. J Med Chem. 1996 Jan 19;39(2):343-6.
8	Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol Scand Suppl. 2013;(197):19-24.
9	1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of pot... J Med Chem. 2008 Oct 23;51(20):6614-8.
10	Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.
11	Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81.