Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7COSH)

Drug Name
(R,S)-4-phosphonophenylglycine Drug Info
Synonyms
(RS)-PPG; 120667-15-4; 2-amino-2-(4-phosphonophenyl)acetic acid; CHEMBL277475; AC1ND7MS; (RS)PPG; (RS) PPG; C8H10NO5P; (RS)-4-Phosphonophenylglycine; GTPL1406; SCHEMBL9150881; CTK8F0597; (R,S)-4-PPG; MolPort-003-983-668; BN0429; BDBM50004881; AKOS015911887; Amino-(4-phosphono-phenyl)-acetic acid; NCGC00025051-02; RT-015313; V2034; Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG); SR-01000597406; 667P154; L000025; SR-01000597406-1; J-004376
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4545574
TTD Drug ID
DM7COSH

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Metabotropic glutamate receptor 8 (mGluR8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-serine-O-phosphate DMTJ1NH Discovery agent N.A. Investigative [3]
[3H]quisqualate DMDQBTX Discovery agent N.A. Investigative [4]
L-CCG-I DMPZ8XH Discovery agent N.A. Investigative [3]
(1S,3R)-ACPD DM5DOAF Discovery agent N.A. Investigative [5]
MAP4 DMUCE93 Discovery agent N.A. Investigative [6]
MPPG DMJHQ9T Discovery agent N.A. Investigative [5]
alpha-methylserine-O-phosphate DMCIH1X Discovery agent N.A. Investigative [7]
L-AP4 DMPJFGI Discovery agent N.A. Investigative [3]
(S)-3,4-DCPG DMG5BUA Discovery agent N.A. Investigative [8]
ACPT-I DM264XN Discovery agent N.A. Investigative [9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
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Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Metabotropic glutamate receptor 8 (mGluR8) TT0IFKL GRM8_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1406).
2 Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. Eur J Pharmacol. 1999 Oct 21;383(1):23-7.
3 Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10.
4 Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9.
5 Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97.
6 Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):180-90.
7 The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317.
8 (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8.
9 Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. Eur J Pharmacol. 2000 Apr 7;394(1):17-26.