Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7T2VQ)

Drug Name

Pyrimidinyl acylthiourea Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Virus RNA-dependent RNA polymerase (Viru RdRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-527	DMARIQK	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[2]
Pyrophosphate 2-	DMZQ75M	Discovery agent	N.A.	Investigative	[3]
Guanosine-5'-Triphosphate	DMV2OJX	Discovery agent	N.A.	Investigative	[4]
Thiadiazolo[2,3-a]pyrimidine	DMKRG2C	Discovery agent	N.A.	Investigative	[1]
T-1105	DMGPQ0Y	Discovery agent	N.A.	Investigative	[1]
FdG	DMYXA7E	Discovery agent	N.A.	Investigative	[1]
T-1106	DMPA2E9	Virus infection	1A24-1D9Z	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Virus RNA-dependent RNA polymerase (Viru RdRP)	TTSUKYD	POLG_HCVJA	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9.
2	AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.