Details of the Drug-Related molecule(s) Interaction Atlas

Coumaranone Drug Info

Benzofuran-3(2H)-one; Benzofuran-3-one; Coumaran-3-one; Coumaranone; MGKPCLNUSDGXGT-UHFFFAOYSA-N; PubChem7023; benzofuran-3 (2h)-one; benzofuran-3-(2H)-one; 1-Benzofuran-3(2H)-one; 1-benzofuran-3-one; 2,3-Dihydrobenzo[b]furan-3-one; 2,3-dihydro-1-benzofuran-3-one; 2-hydrobenzo[b]furan-3-one; 2H-3-Benzofuranone; 2H-BENZOFURAN-3-ONE; 2H-BEZOFURAN-3-ONE; 3(2H)-BENZOFURANONE; 3-(2H)-benzo[b]furanone; 3-BENZOFURANONE; 3-Coumaranone; 7169-34-8; 71699-34-8; AC1L2MLQ; CCRIS 3596; MFCD00051810; NCIOpen2_003700; SCHEMBL69412

Cross-matching ID

PubChem CID

23556

CAS Number

CAS 7169-34-8

TTD Drug ID

DM7TCPG

INTEDE Drug ID

DR2011

General Information of Drug (ID: DM7TCPG)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Loteprednol Etabonate	DM8QTJI	Eye inflammation	9A02	Approved	[2]
Prulifloxacin	DMOK965	Urinary tract infection	GC08	Approved	[3]
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[1]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[1]
gamma-butyrolactone	DMDCZWY	Discovery agent	N.A.	Investigative	[1]
Dihydrocoumarin	DMGLX1R	N. A.	N. A.	Investigative	[1]
Gamma-thiobutyrolactone	DM83HUI	N. A.	N. A.	Investigative	[1]
Homogentisic acid	DMQD0YW	N. A.	N. A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Serum paraoxonase/arylesterase 1 (PON1)^{Main DME}	DESDN74	PON1_HUMAN	Substrate	[1]

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References

1	Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.
2	Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.
3	Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.