Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7Y4GT)

Drug Name

T-226293 Drug Info

Synonyms

Triparanol; TRIPARANOL; Metasqualene; MER 29; 78-41-1; triparanolum; valip; Metasclene; Clotrox; Triparanolo [DCIT]; Hipocolestina; Acosterina; Drenaren; Diticyl; Triparanol [INN:BAN]; Triparanolum [INN-Latin]; EINECS 201-115-0; NSC 65345; BRN 2064866; 1-(4-(2-Diethylaminoethoxy)phenyl)-1-p-tolyl-2-(4-chlorophenyl)ethanol; CHEMBL187709; 2-p-Chlorophenyl-1-(p-(2-diethylaminoethoxy)phenyl)-1-p-tolylethanol; 1-(4-(2-(Diethylamino)ethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol; NCGC00165907-02

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Preclinical	[1]

Cross-matching ID

PubChem CID: 6536
ChEBI ID: CHEBI:135714
CAS Number: CAS 78-41-1
TTD Drug ID: DM7Y4GT

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Melanin-concentrating hormone receptor 1 (MCHR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMS-830216	DMCW71N	Obesity	5B81	Phase 1	[3]
AZD1979	DMQ1OX4	Obesity	5B81	Phase 1	[4]
PMID25522065-Compound-27	DMXN4KB	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-29	DMBNAK9	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-34	DMZDIRQ	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-39	DM5YMQH	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-40	DMCIQ01	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-11	DM410Z6	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-50	DMBWA0V	N. A.	N. A.	Patented	[5]
PMID25522065-Compound-12	DMVKO9C	N. A.	N. A.	Patented	[5]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazacholesterol	DM5DPM4	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Delta(24)-sterol reductase (DHCR24)	TTTK0NH	DHC24_HUMAN	Inhibitor	[2]
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Antagonist	[1]

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References

1	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
2	Antilipemic drug-induced skin manifestations. Hautarzt. 1995 Feb;46(2):76-80.
3	2011 Pipeline of Bristol-Myers Squibb.
4	Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc
5	Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207.