Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTTK0NH)

DTT Name Delta(24)-sterol reductase (DHCR24)
Synonyms Seladin-1; Diminuto/dwarf1 homolog; DHCR24
Gene Name DHCR24
DTT Type
Literature-reported target
 [1]
BioChemical Class
CH-CH donor oxidoreductase
UniProt ID
DHC24_HUMAN
TTD ID
T90935
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
EC 1.3.1.72
Sequence
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKL
SSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMD
ILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKY
GLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKL
RFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYY
KPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVP
PKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQ
PGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREE
FWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
Function
Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
KEGG Pathway
Steroid biosynthesis (hsa00100 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Cholesterol biosynthesis (R-HSA-191273 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Preclinical Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
T-226293 DM7Y4GT Obesity 5B81 Preclinical [1]
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1 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazacholesterol DM5DPM4 Discovery agent N.A. Investigative [1]
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The Drug-Metabolizing Enzyme (DME) Role of This DTT

DTT DME Name Delta(24)-sterol reductase (DHCR24) DME Info
Gene Name DHCR24
1 Investigative Drug(s) Metabolized by This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
desmosterol DMV8SUM Discovery agent N.A. Investigative [2]
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References

1 Antilipemic drug-induced skin manifestations. Hautarzt. 1995 Feb;46(2):76-80.
2 Alzheimer's disease: brain desmosterol levels. J Alzheimers Dis. 2013;33(3):881-8.