Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM814EQ)

Drug Name
N-6547 Drug Info
Indication
Disease Entry ICD 11 Status REF
Inflammatory bowel disease DD72 Investigative [1]
Cross-matching ID
TTD Drug ID
DM814EQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutathione reductase (GR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oxidized glutathione DM9EQC0 Breast cancer 2C60-2C65 Approved [2]
Golden phosphorous acetyletic compound 2 DMYJ15A N. A. N. A. Patented [3]
Terpyridineplatinum(II) complexe 3 DM54EFD N. A. N. A. Patented [3]
Terpyridineplatinum(II) complexe 4 DMOV86T N. A. N. A. Patented [3]
Golden phosphorous acetyletic compound 1 DMVAKUI N. A. N. A. Patented [3]
Acyl oxymethyl acrylamide ester derivative 1 DMXTUE1 N. A. N. A. Patented [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [4]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [4]
3-Sulfinoalanine DMILTRN N. A. N. A. Investigative [4]
1-(2'-chlorophenyl)penta-1,4-dien-3-one DMKTZSY Discovery agent N.A. Investigative [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutathione reductase (GR) TTEP6RV GSHR_HUMAN Inhibitor [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2613).
2 The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401.
3 Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.