General Information of Drug (ID: DM8B1Q4)

Drug Name
US8889672, 252-036-001 Drug Info
Synonyms SCHEMBL13837647; CHEMBL2393427; BDBM139472; US8889672, 252-036-001
Cross-matching ID
PubChem CID
71009752
TTD Drug ID
DM8B1Q4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methyl 2-amino-4-phenylthiophene-3-carboxylate DM9BYJ0 N. A. N. A. Patented [1]
Y-9680 DMHAVYS N. A. N. A. Patented [1]
US8889696, 39 DMKXRJ4 N. A. N. A. Patented [2]
RO-320432 DMFZ1YW N. A. N. A. Terminated [3]
LY-317644 DMM20PI N. A. N. A. Terminated [4]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [5]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [6]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [7]
[2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F Discovery agent N.A. Investigative [8]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein kinase C zeta (PRKCZ) TTUWGRA KPCZ_HUMAN Inhibitor [1]

References

1 Compounds, formulations, and methods of protein kinase C inhibition. US8889672.
2 Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof. US8889696.
3 Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).
4 Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995).
5 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
6 Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15.
7 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
8 Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.
9 Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83.